Ponente: Julia Rubio Loscertales (Jose Requejo-Isidro’s lab, Centro Nacional de Biotecnología (CNB-CSIC))

Lugar: Seminario Mirian Andrés (Edificio CCT).

Hora: jueves 13 de marzo de 2025, 09:10.

Resumen: Single-Molecule Tracking (SMT) is a powerful technique for quantifying and understanding dynamic biological processes. It involves localizing fluorescent particles in a video and following them over time to analyze their movement patterns.

For our system of interest—homogeneous Supported Lipid Bilayers (SLBs)—theoretical models predict purely random motion for individual lipids. However, experimental observations reveal a much more diverse behavior. In this work, we propose a refined model for experimental SLBs that incorporates three distinct types of movement: a random Brownian component, a directional component, and a quiescent state. We test this hypothesis by comparing two analytical approaches; a weighted non-linear least squares fit and a probabilistic Hidden Markov Model (HMM).